Now Is The Time To Build With Bio
Nature is the greatest chemist. We have the opportunity to harness that greatness.
Smiles expected, not guaranteed.
Big Problems = Big Opportunities
Biomanufacturing: Deep Tech's Most Exciting Sector
Biomanufacturing pairs biology with engineering to make everyday chemicals at industrial scale. Biomanufacturing uses biomass as a feedstock, and aims to use less inputs than traditional processes.
Less Carbon
Less Water
Less Waste
The world of biomanufacturing allows us to harness living cells to produce cleaner ingredients for everyday products.
Broadly speaking, biomanufacturing can be broken into 3 major categories;
Industrial Chemicals - materials, chemicals, fuels, etc.
Agrochemicals - fungicides, herbicides, pesticides, etc.
Hardware & Software - novel bioreactors, process optimization, etc.
Check out some of the ways that biomanufacturing is shaping our future
The next industrial revolution
Nature Is Earth's Most Powerful Chemist
We can now use sugars, starches, and waste to make everyday products. No more oil wells, smokestacks, or toxic-byproducts. That was so 20th century.
We live in an industrial era where renewable feedstocks flow into clean reactors and come out as the same high-performance everyday chemicals you already depend on.
Here's how it works:
Renewable Feedstocks (Algae, Ag Waste, Food Waste, and Industrial Gasses) Are Used As Inputs
Processes Technologies Use Biological and Chemical Processes To Convert Biomass
Commodity and Specialty Chemicals Are Produced To Serve Dozens of Different Markets
The solution society is waiting for
4 Key Challenges Solved By Biomanufacturing
Biomanufacturing tackles planet-scale challenges and is positioned set to reshape everyday life.
Analysts project the bioeconomy will grow into a $30+ trillion global market.
Human Health
Bio-based polymers replace microplastic-shedding plastics with safer, plant-made materials. Less benzene and other toxins means cleaner air, food, and better health outcomes.
Environment
Biomanufacturing slashes water, energy, and CO₂ compared with oil-based production. Fewer inputs in, cleaner molecules out = same products with a radically smaller footprint.
National Security
America imports 90%+ of tire isoprene and most acrylic acid from strategic rivals. Domestic biomanufacturing brings these critical feedstocks back onshore and under U.S. control.
Waste Reduction
Microbes now turn farm methane into acrylic acid and food scraps into premium lubricants. Waste streams become profit streams, shrinking landfills and emissions at the same time.
Tailwinds Driving Change
Now Is The Time To Invest In Bio
A rare alignment of cheap biotech tools, climate-driven consumer demand, corporate net-zero promises, and billions in public funding makes this the breakout decade for biomanufacturing investment.
Here are a few factors driving change:
Consumer Awareness - Shoppers are rejecting toxins & microplastics, pushing brands toward cleaner inputs.
Technological Advances - AI design and $500 genome sequencing cut R&D cycles from years to weeks.
Sustainability Initiatives – Net-zero mandates compel companies to swap fossil feedstocks for renewables.
Government Funding - Billions are being poured into on-shoring biomanufacturing plants and talent.
Become an expert in 60 minutes
Biomanufacturing Bundle™
Get instant access to:
Biomanufacturing DDQ (For Due Diligence)
Biomanufacturing Meta Analysis
Biomanufacturing Graveyard
Biomanufacturing Masterclass
Total value: $997
Today $0
"The unlock code"
"This is the quickest way to shorten your learning curve on all things biomanufacturing." - Jesse Henry
Laser Focused on meaningful outcomes
Why First Bight Is Positioned To Lead
The Biomanufacturing Revolution
If you are looking for silent capital, you are in the wrong place.
Strategic Capital
The leading VC firm investing exclusively in biomanufacturing.
Ecosystem Builder
We cultivate the entire value chain to advance commercial production.
Hands On Support
We guide leadership teams towards lean, cost effective operations.
BioWell Accelerator
Our incubator helps companies optimize processes & scale with bio.
Scalable Infrastructure
We help teams generate samples, find customers, and optimize ops.
Houston Advantage
We live in the heart of the materials and energy transitions.
Why Houston?
Houston: The Launchpad of The Bio Revolution
Sitting at the crossroads of energy, logistics, and life-science talent, Houston offers the critical ingredients - people, plants, and pipelines - that turn lab breakthroughs into global biomanufacturing ventures.
100,000+ Biotech Scientists and Specialists
200,000+ Total STEM Professionals
Leading Hub For Global Chemical Companies
2nd Largest Manufacturing Hub In the United States
World-class Ports, Pipelines, and Rail Logistics
Home To The World's Largest Medical Center
4th Largest Engineering Workforce In The Nation
And Sometimes, we like to have fun
The Secret Sauce of Biomanufacturing
Smiles expected, not guaranteed.
Data Supporting The Transition
Biomanufacturing Reports & Studies
Published By Industry Leaders
Biomanufacturing tackles planet-scale challenges and is positioned set to reshape everyday life.
Analysts project the bioeconomy will grow into a $30+ trillion global market.
Alliance Bernstein
Genome sequencing has plunged a million-fold - from hundreds of millions of dollars to hundreds
McKinsey
60% of all physical inputs to the global economy could be produced biologically
Boston Consulting Group
Syn-bio could be deployed to make up > 1⁄3 of global output - ≈ $30 trillion by 2030
Synonym Biotechnology
China and the EU are pouring public money into new bio assets, threatening the current U.S. lead
United States Congress
1.3 billion tons of U.S. biomass can be harvested sustainably each year
The White House
China is “rapidly becoming a leader” in biobased production, echoing our semiconductor industry
Chemical Engineering Progress
The U.S. must rapidly build pilot-to-commercial capacity and a new bio-skilled workforce
Schmidt Futures
Biomanufacturing can add 1.1 million new jobs and $260 billion in annual economic activity
Synonym Biotechnology
China and the EU are pouring public money into new bio assets, threatening the current U.S. lead
Boston Consulting Group
The U.S. must rapidly build pilot-to-commercial capacity and a new bio-skilled workforce
Press from port co's
News From Our Portfolio
Stay up to date on advancements from First Bight's portfolio companies.
Persephone
January 23, 2025
Persephone Biosciences Announces First Subject Enrolled in ARTEMIS Clinical Trial of New Infant Synbiotic
Global Newswire
Oct 19, 2023
Persephone Biosciences Announces New Collaboration With Kroger Health to Launch AMBROSIA Food as Medicine Study
BioSpace
Oct 17, 2023
Persephone Biosciences and Ginkgo Bioworks Complete Reusable Bacteroides Anaerobic Engineering Toolkit
Cision
July 27, 2023
Building a Better Microbiome
proto.life
April 27, 2023
“Cancer & the Gut Biome” with Stephanie Culler, Ph.D.
Angel Invest Boston
Jan 24, 2023
Kroger Health Establishes Clinical Trial Site Network to Increase Reach and Access to Research Studies
Cision
Sept 20, 2022
Persephone Biosciences Announces First Participant Enrolled in the ARGONAUT Study of Gut Microbiome-Linked Immune Modulation in Cancer Treatment Response
GlobeNewswire
July 19, 2022
Persephone Biosciences, Pioneers In Synthetic Biology, Lands $15M In Seed Funding
Grit Daily
July 19, 2022
Can bacteria in your gut boost cancer therapies? A San Diego startup thinks so
The San Diego-Union Tribune
July 19, 2022
Persephone puts poop to work to explore and heal your gut microbiome
TechCrunch
Visolis
July 30, 2024
Visolis Receives $2.25M DOD Award to Plan for Domestic Facility
U.S. Dept. of Defense
April 10, 2024
Zeon and Visolis collaborating on commercialization of bio-isoprene monomers
Chemical Engineering
October 26, 2023
Goodyear, Visolis partner for bio-based isoprene
Rubber News
July 20, 2023
Harnessing synthetic biology to make sustainable alternatives to petroleum products
MIT
April 24, 2023
Visolis and Ginkgo Bioworks Announce Partnership to Improve Microbial Strain
Ginkgo Bioworks
Jan 11, 2023
Biomanufacturing Startup Visolis Has Raised $8 Million To Make Carbon-Negative Materials
Forbes
Sept 19, 2019
Visolis Recognized as One of “the 50 Next Companies to Disrupt the World”
The Digest
Algenesis
April 28, 2025
Why Most “Biodegradable” Products Are Probably Fake
Business Insider
February 1, 2025
Flow chemistry yields a more sustainable route to isocyanates
Chemical Engineering Magazine
Sept 16, 2024
DoD Releases 12 Awards for Distributed Bioindustrial Manufacturing Program
June 27, 2024
How Biodegradable Polyurethane Could Solve the Microplastic Pollution Problem
March 24, 2024
May 10, 2023
September 21, 2022
Sustainability Matters: Sanuk Debuts Plant-Based, Carbon-Neutral Sneakers + More News
Footwear News
Capra Biosciences
July 19, 2024
Capra Biosciences Lands $7.5 Million Project Agreement To Demonstrate Platform To Rapidly Scale Pharmaceutical Ingredient Manufacturing
Capra Biosciences
April 29, 2024
How Microbes Are Changing Manufacturing: Why We Invested in Capra Biosciences
Closed Loop Partners
Industrial Microbes
Nov 19, 2024
Industrial Microbes announces seed round funding
iMicrobes Press
Nov 4, 2024
A low-cost method for bio-based production of acrylic acid
Chemical Engineering
September 14, 2023
DoD Releases Seven Awards for Distributed Bioindustrial Manufacturing Program
BioMADE
September 14, 2023
BioMADE Announces Nine Projects, $18.7 Million to Advance Domestic Bioindustrial Manufacturing and DoD Sustainability Goals
BioMADE
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